منابع مشابه
Molecular diagnostics of calcineurin-related pathologies.
BACKGROUND The Ca(2+)-dependent protein phosphatase enzyme calcineurin (Cn) (protein phosphatase 3) is best known for its role as director of the adaptive immune response. One of its principal substrates is the nuclear factor of activated T cells (NFAT), which translocates to the nucleus after dephosphorylation to mediate gene transcription. Drugs targeting Cn (the Cn inhibitors tacrolimus and ...
متن کاملPrecision medicine, technologies, and molecular diagnostics
Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...
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The laboratory medicine is advancing towards the use of molecular techniques and molecular diagnostics for the detection of leukemia, genetic disorders, preimplantation screenings, pharmacogenomics, infectious diseases, and cancers. Molecular diagnostics dates back to 1980s but now has grown exponentially. The field has a wide range of applications including identifying individuals at risk of d...
متن کاملMolecular Diagnostics
Our understanding of the function of human DNA, known as the human genome, is steadily progressing. Cytogenetic methods have been in clinical use since the 1960s, and molecular tests for almost 2,500 rare monogenic disorders since the 1980s. Recently, genetic testing has also become an important tool in studies of familial cancer predisposition, where the numbers of those benefiting from testin...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2012
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2011.167296